苏博美利奴羊毛囊发育相关lncRNA与mRNA共表达网络的构建

陈华峰,田可川,黄锡霞,阿布来提·苏来曼,何军敏,田月珍,徐新明,付雪峰,赵冰茹,朱桦,哈尼克孜·吐拉甫

Construction of Co-expression Network of lncRNA and mRNA Related to Hair Follicle Development of Subo Merino Sheep

HuaFeng CHEN,KeChuan TIAN,XiXia HUANG,Sulayman Ablat,JunMin HE,YueZhen TIAN,XinMing XU,XueFeng FU,BingRu ZHAO,Hua ZHU,Tulafu Hanikezi

表3 目标模块部分GO富集

Table 3 Part GO enrichment results of the target modules

模块 Module ID GO条目 GO Term 基因数 No. genes P值 P value 基因 Genes honeydew1 GO:0090090 经典Wnt信号通路负调控 Negative regulation of canonical Wnt signaling pathway 12 4.26E-06 WNT5A, CTHRC1, SOX10, NOG, SOST, SFRP2, DRAXIN, SOX2, LIMD1, LRP4, MLLT3, GLI1 GO:0043588 皮肤发育 Skin development 6 5.74E-04 FRAS1, TFAP2B, PTCH2, LTB, COL5A2, COL5A1 GO:0050680 上皮细胞增殖负调控 Negative regulation of epithelial cell proliferation 6 3.77E-03 WNT5A, HPN, SFRP2, SOX2, PTCH1, TGFB2 GO:0001942 毛囊发育 Hair follicle development 5 7.28E-03 INHBA, EDAR, ALX4, LRP4, TGFB2 GO:0030514 BMP信号通路负调控 Negative regulation of BMP signaling pathway 5 1.28E-02 WNT5A, NOG, SOST, BMPER, SFRP2 GO:0007155 细胞粘附 Cell adhesion 8 2.24E-02 LAMA1, HES5, TLN2, ITGA11, CNTN2, CNTN4, THBS2, COL5A1 paleturquoise GO:0043588 皮肤发育 Skin development 6 2.68E-02 KRT9, COL3A1, ITGB4, ADAMTS2, ASPRV1, DHCR24 GO:0031069 毛囊形态发生 Hair follicle morphogenesis 5 1.89E-02 KRT25, KRT27, FOXE1, KRT71, TMEM79 GO:0007173 表皮生长因子受体信号通路 Epidermal growth factor receptor signaling pathway 6 1.62E-02 FAM83B, EREG, HBEGF, TGFA, AREG, SOX9 GO:0001942 毛囊发育 Hair follicle development 6 4.11E-02 DSG4, ZDHHC21, FOXN1, SOX9, DNASE1L2, LGR5 skyblue2 GO:0090090 经典Wnt信号通路负调控 Negative regulation of canonical Wnt signaling pathway 9 1.49E-02 WNT4, NOTCH1, WNT5B, SFRP4, FZD1, FOXO1, ISL1, FRZB, PTPRO GO:0007155 细胞粘附 Cell adhesion 16 4.20E-05 CTNNAL1, HAPLN1, TNC, COL15A1, ITGA3, POSTN, STAB2, GRHL2, TNFAIP6, ITGA9, LYVE1, TGFBI, VCAN, CNTN3, NCAN, SPP1