Given the public concern over the safety of genetically modified (GM) technology and products, the article elaborated the safety regulatory and administration on agricultural GMOs in China. China has made a set of laws and regulations of GMO safety management and confirmed competent authorities with clear-cut responsibilities. According to the laws and regulations, GMO products before entering markets have to pass through safety evaluation, get production and processing permission and be labeled correctly. For the importation of GM products, China has set up an import approval system. In addition, China has established technical supportive systems, including safety evaluation specifications, trial specifications and criteria specifications. The existing regulatory system supervises and regulates all activities and work related to agricultural GMOs in China.