Faced with the scarcity of water resources and irrational fertilizer use, it is critical to supply plants with water and fertilizer in a coordinated pattern to improve yield with high water use efficiency (WUE).  One such method, alternate partial root-zone irrigation (APRI), has been practiced worldwide, but there is limited information on the performance of different irrigation regimes and nitrogen (N) rates under APRI.  The objectives of this study were to investigate the effects of varying irrigation regimes and N rates on shoot growth, grain yield and WUE of maize (Zea mays L.) grown under APRI in the Hexi Corridor area of Northwest China in 2014 and 2015.  The three N rates were 100, 200 and 300 kg N ha^–1, designated N₁, N₂ and N₃, respectively.  The three irrigation regimes of 45–50%, 60–65% and 75–80% field capacity (FC) throughout the maize growing season, designated W₁, W₂ and W₃, respectively, were applied in combination with each N rate.  The results showed that W₂ and W₃ significantly increased the plant height, stem diameter, crop growth rate, chlorophyll SPAD value, net photosynthetic rate (P_n), biomass, grain yield, ears per ha, kernels per cob, 1 000-kernel weight, harvest index, evapotranspiration and leaf area index (LAI) compared to W₁ at each N rate.  The N₂ and N₃ treatments increased those parameters compared to N₁ in each irrigation treatment.  Increasing the N rate from the N₂ to N₃ resulted in increased biomass and grain yield under W₃ while it had no impact on those under the W₁ and W₂ treatments.  The W₃N₃ and W₂N₂ and W₂N₃ treatments achieved the greatest and the second-greatest biomass and grain yield, respectively.  Increasing the N rate significantly enhanced the maximum LAI (LAI at the silking stage ) and P_n under W₃, suggesting that the interaction of irrigation and fertilizer N management can effectively improve leaf growth and development, and consequently provide high biomass and grain yield of maize.  The W₂N₂, W₂N₃ and W₃N₃ treatments attained the greatest WUE among all the treatments.  Thus, either 60–65% FC coupled with 200–300 kg N ha^–1 or 75–80% FC coupled with 300 kg N ha^–1 is proposed as a better pattern of irrigation and nitrogen application with positive regulative effects on grain yield and WUE of maize under APRI in the Hexi Corridor area of Northwest China and other regions with similar environments.  These results can provide a basis for in-depth understanding of the mechanisms of grain yield and WUE to supply levels of water and nitrogen.