本研究以东北农业大学肉鸡高、低腹脂双向选择品系1-7周龄鸡只和永生化鸡前脂肪细胞（ICP2细胞）为材料，利用RT-qPCR和Western blot方法分析HBP1在脂肪组织和前脂肪细胞分化过程中的表达模式；以稳定过表达HBP1的ICP2细胞、敲除HBP1的ICP2细胞以及各自的对照细胞为材料，利用油红O染色、RT-qPCR和Western blot检测过表达/敲除HBP1对鸡前脂肪细胞分化的影响；利用信号通路分析试剂盒筛选HBP1调控鸡前脂肪细胞分化的潜在信号通路；在稳定过表达HBP1的ICP2细胞中添加信号转导和转录激活因子3（STAT3）的化学抑制剂或转染siRNA进行功能拯救实验。结果：基因表达分析结果表明，HBP1的表达与鸡腹部脂肪沉积和前脂肪细胞分化有关。过表达HBP1抑制鸡前脂肪细胞分化（P<0.05），敲除HBP1促进鸡前脂肪细胞分化（P<0.05）。进一步研究发现，HBP1靶向激活Janus激酶2（JAK2）基因的转录来激活STAT3信号通路。功能拯救实验结果表明，STAT3信号介导了HBP1对鸡前脂肪细胞分化的调控作用。以上结果表明，HBP1通过直接上调JAK2的表达来激活STAT3信号通路，从而抑制鸡前脂肪细胞的分化。本研究阐明了HBP1在鸡前脂肪细胞分化中的基本功能，并揭示了其部分分子机制。这些发现为进一步解析鸡脂肪组织生长发育的分子遗传基础提供了新的见解。

A hydroponic study was conducted to determine the effects of selenium (Se: 0, 3, 6 μmol L−1) on senescence-related oxidative stress in garlic plants grown under two sulfur (S) levels. We evaluated the yields of plants harvested at 160 and 200 days after sowing. Plants grown under a low Se dose (0.3 μmol L−1) at low S level showed higher yields (12.0% increase in fresh weight yield, 13.7% increase in dry weight yield) than the controls, despite a decrease in chlorophyll concentration. Compared with control plants, the Se-treated plants showed lower levels of lipid peroxidation. The Se-treated plants also showed higher activities of glutathione peroxidase and catalase, but lower superoxide dismutase activities. Changes in Fv/Fm values and proline contents were affected more strongly by S than by Se. On the basis of our results, we can conclude that Se plays a key role in the antioxidant systems in garlic seedlings. It delays senescence by alleviating the peroxide stress, but it can be toxic at high levels. A high S level may increase tolerance to high Se concentrations through reducing Se accumulation in plants.