Journal of Integrative Agriculture ›› 2012, Vol. 12 ›› Issue (11): 1871-1876.DOI: 10.1016/S1671-2927(00)8722

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StimulationStudyofGenePyramiding inAnimals byMarker-AssistedSelection

  href="https://www.chinaagrisci.com/Jwk_zgnykxen/CN/article/advancedSearchResult.do?searchSQL=(((ZHAO Fu-ping[Author]) AND 1[Journal]) AND year[Order])" target="_blank">ZHAO Fu-ping,  ZHANG Qin   

  1. 1.National Center for Molecular Genetics and Breeding of Animal, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences,Beijing 100193, P.R.China
    2.Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture/College of Animal Science and Technology,China Agricultural University, Beijing 100193, P.R.China
  • 收稿日期:2011-09-20 出版日期:2012-11-01 发布日期:2012-11-24
  • 通讯作者: Correspondence ZHANG Qin, Tel/Fax: +86-10-62732634, E-mail: qzhang@cau.edu.cn
  • 作者简介:ZHAO Fu-ping, E-mail: zfpcau@gmail.com;
  • 基金资助:

    This work was supported by the National Major Special Project of China on New Varieties Cultivation for Transgenic Organisms (2009ZX08009-146B) and by the National Non-profit Institute Research Grant, China (2012cj-2).

StimulationStudyofGenePyramiding inAnimals byMarker-AssistedSelection

 ZHAO Fu-ping,  ZHANG Qin   

  1. 1.National Center for Molecular Genetics and Breeding of Animal, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences,Beijing 100193, P.R.China
    2.Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture/College of Animal Science and Technology,China Agricultural University, Beijing 100193, P.R.China
  • Received:2011-09-20 Online:2012-11-01 Published:2012-11-24
  • Contact: Correspondence ZHANG Qin, Tel/Fax: +86-10-62732634, E-mail: qzhang@cau.edu.cn
  • About author:ZHAO Fu-ping, E-mail: zfpcau@gmail.com;
  • Supported by:

    This work was supported by the National Major Special Project of China on New Varieties Cultivation for Transgenic Organisms (2009ZX08009-146B) and by the National Non-profit Institute Research Grant, China (2012cj-2).

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摘要： This gene pyramiding strategy is based on the idea of efficiently pyramiding genes of interest by crosses and selection to obtain a population with favorable alleles from different breeds or lines, which is called an ideal population. We investigate impacts of some factors on the pyramiding efficiencies by simulation. These factors include selection strategies (the breeding value selection, the molecular scores selection and the index selection), proportion selected (2, 10 and 20%), recombination rates between adjacent target genes (0.1, 0.3 and 0.5) and different mating types (the random mating and the positive assortative mating avoiding sib mating). The results show that: (1) The more recombination rate and the lower proportion male selected, the better pyramiding efficiency; (2) the ideal population is obtained via various selection strategies, while different selection strategies are suitable for different breeding objectives. From the perspective of pyramiding target genes merely, the molecular scores selection is the best one, for the purpose of pyramiding target genes and recovering genetic background of the target trait, the index selection is the best one, while from the saving cost point of view, the breeding value selection is the best one; (3) the positive assortative mating is more efficient for gene pyramiding compared with the random mating in the terms of the number of generations of intercross for getting the ideal population.

关键词: gene pyramiding, pyramiding efficiency, selection strategies, mating types

Abstract: This gene pyramiding strategy is based on the idea of efficiently pyramiding genes of interest by crosses and selection to obtain a population with favorable alleles from different breeds or lines, which is called an ideal population. We investigate impacts of some factors on the pyramiding efficiencies by simulation. These factors include selection strategies (the breeding value selection, the molecular scores selection and the index selection), proportion selected (2, 10 and 20%), recombination rates between adjacent target genes (0.1, 0.3 and 0.5) and different mating types (the random mating and the positive assortative mating avoiding sib mating). The results show that: (1) The more recombination rate and the lower proportion male selected, the better pyramiding efficiency; (2) the ideal population is obtained via various selection strategies, while different selection strategies are suitable for different breeding objectives. From the perspective of pyramiding target genes merely, the molecular scores selection is the best one, for the purpose of pyramiding target genes and recovering genetic background of the target trait, the index selection is the best one, while from the saving cost point of view, the breeding value selection is the best one; (3) the positive assortative mating is more efficient for gene pyramiding compared with the random mating in the terms of the number of generations of intercross for getting the ideal population.