构建可降解的三重刺激响应型介孔有机硅纳米载体，用于水稻病害管理中的靶向农药递送与增强植物免疫力

doi:10.1016/j.jia.2025.06.019

Journal of Integrative Agriculture ›› 2026, Vol. 25 ›› Issue (6): 2496-2509.DOI: 10.1016/j.jia.2025.06.019

构建可降解的三重刺激响应型介孔有机硅纳米载体，用于水稻病害管理中的靶向农药递送与增强植物免疫力

收稿日期:2025-03-08 修回日期:2025-06-10 接受日期:2025-05-19 出版日期:2026-06-20 发布日期:2026-05-06

Development of biodegradable triple-stimuli-responsive mesoporous organosilica nanocarriers for targeted pesticide delivery and enhanced plant immunity in rice disease management

Yuchen Song¹, Sijin Wang¹, Yuehong Du¹, Zhenyu Li¹, Yumeng Yuan¹, Yihan Chen¹, Wanwan Wang², Hongqiang Dong³, Zhongyang Huo¹, You Liang^{1, 4#}

¹Co-Innovation Center for Modern Production Technology of Grain Crops/Jiangsu Key Laboratory of Crop Genetics and Physiology/Research Institute of Rice Industrial Engineering Technology, Yangzhou University, Yangzhou 225009, China
²Jiangsu Key Laboratory of Chiral Pharmaceuticals Biosynthesis, Taizhou University, Taizhou 225300, China
³College of Agriculture, Tarim University, Alaer 843300, China
⁴State Key Laboratory of Green Pesticides/Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education/Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, China

Received:2025-03-08 Revised:2025-06-10 Accepted:2025-05-19 Online:2026-06-20 Published:2026-05-06
About author:Yuchen Song, E-mail: m18852712482@163.com; #Correspondence You Liang, Tel: + 86-514-87972363, E-mail: liangyou@yzu.edu.cn
Supported by:
This work was supported by the National Natural Science Foundation of China (32102293), the Carbon Peak Carbon Neutral Science and Technology Innovation Special Fund of Jiangsu Province, China (BE2022424), the Earmarked Fund for China Agricultural Research System (CARS-01-26), the Jiangsu Agricultural Science and Technology Innovation Fund, China (CX(22)1001), the Bingtuan Science and Technology Program, China (2024DA004), the Taizhou Science and Technology Support Program (Agriculture) Project, China (TN202222), the Postgraduate Research & Practice Innovation Program of Jiangsu Province, China (KYCX23_3578), the College Students’ Innovative Entrepreneurial Training Plan Program, China (202411117194Y and XCX20240676), and the Priority Academic Program Development of Jiangsu Higher Education Institutions, China (PAPD).

摘要/Abstract

摘要：

开发新型刺激响应型农药递送系统是提高农药利用率并降低环境风险的有效策略。本研究通过将壳寡糖（COS）共价接枝至含有可降解二硫键的有机介孔二氧化硅纳米颗粒（MONs），并负载吡唑醚菌酯（PYR），成功构建了一种pH/谷胱甘肽/几丁质酶三重刺激响应的农药递送系统。该系统的载药量为 13.6%，其 COS 修饰层可有效保护活性成分免受光降解，并防止 PYR 过早释放。在稻瘟病菌（Magnaporthe oryzae）侵染过程中，感染部位的pH降低、谷胱甘肽浓度升高以及几丁质酶酶活性增强可协同触发二硫键断裂与 COS 酶解，实现 PYR 的靶向快速释放。此外，PYR@MONs-COS显著提升了PYR在水稻叶片中的渗透能力和农药液滴的附着性能，并诱导水稻叶片细胞中胼胝质的沉积，提高了水稻自身的免疫力。离体和活体抗菌活性结果表明，与PYR微胶囊相比，PYR@MONs-COS对水稻稻瘟病表现出更好的防效和更长的持效期。安全性评估表明，PYR@MONs-COS对水稻无明显毒性，且对斑马鱼的急性毒性相比原药降低了7.3倍。因此，这种三重刺激响应的农药递送系统在水稻病害防治中具有广阔的应用前景，并为可持续农业的发展提供了一条有前景的途径。

Abstract:

The development of novel stimuli-responsive pesticide delivery systems is a highly effective strategy for improving pesticide utilization efficiency while minimizing environmental risks. A pH-, glutathione-, and chitinase-responsive pesticide delivery system (PYR@MONs-COS) was designed by conjugating chitosan oligosaccharide (COS) with biodegradable disulfide bond-bridged mesoporous silica nanoparticles (MONs) loaded with pyraclostrobin (PYR). The loading capacity of PYR in the nanoparticles was approximately 13.6%. The covalent attachment of COS to the modified MONs could effectively protect the active ingredient from photodegradation and prevent premature release of PYR. During the infection process, physiological and biochemical changes at the infection site, including reduced pH values, increased glutathione levels, and enhanced chitinase activity, facilitated the rapid degradation of disulfide bonds and COS in PYR@MONs-COS, resulting in the rapid release of PYR. Furthermore, PYR@MONs-COS significantly enhanced the foliar penetration of PYR, improved the adhesion of pesticide droplets, and stimulated callose deposition in rice leaves, thereby enhancing rice immunity. In antifungal activity assays, PYR@MONs-COS exhibited superior efficacy and prolonged efficacy against Magnaporthe oryzae compared to PYR microcapsules in both in vitro and in vivo experiments. The phytotoxicity assessment indicated that PYR@MONs-COS was safe for rice plants. More importantly, PYR@MONs-COS demonstrated a 7.3-fold reduction in acute toxicity to zebrafish compared to PYR technical. Therefore, the triple-stimuli pesticide delivery system has great potential for rice disease management and provides a promising pathway for the development of sustainable agriculture.

Key words: mesoporous organosilica nanoparticles , stimuli-responsive pesticide delivery , chitosan oligosaccharide , rice disease management , plant immunity

Yuchen Song, Sijin Wang, Yuehong Du, Zhenyu Li, Yumeng Yuan, Yihan Chen, Wanwan Wang, Hongqiang Dong, Zhongyang Huo, You Liang. 构建可降解的三重刺激响应型介孔有机硅纳米载体，用于水稻病害管理中的靶向农药递送与增强植物免疫力[J]. Journal of Integrative Agriculture, 2026, 25(6): 2496-2509.

Yuchen Song, Sijin Wang, Yuehong Du, Zhenyu Li, Yumeng Yuan, Yihan Chen, Wanwan Wang, Hongqiang Dong, Zhongyang Huo, You Liang. Development of biodegradable triple-stimuli-responsive mesoporous organosilica nanocarriers for targeted pesticide delivery and enhanced plant immunity in rice disease management[J]. Journal of Integrative Agriculture, 2026, 25(6): 2496-2509.

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构建可降解的三重刺激响应型介孔有机硅纳米载体，用于水稻病害管理中的靶向农药递送与增强植物免疫力

Development of biodegradable triple-stimuli-responsive mesoporous organosilica nanocarriers for targeted pesticide delivery and enhanced plant immunity in rice disease management

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