Emergence of H5N1 highly pathogenic avian influenza in Democratic People’s Republic of Korea

doi:10.1016/S2095-3119(21)63829-7

Journal of Integrative Agriculture ›› 2022, Vol. 21 ›› Issue (5): 1534-1538.DOI: 10.1016/S2095-3119(21)63829-7

收稿日期:2021-05-28 接受日期:2021-08-27 出版日期:2022-05-01 发布日期:2021-08-27

Emergence of H5N1 highly pathogenic avian influenza in Democratic People’s Republic of Korea

LIU Li-ling¹, YANG Huan-liang¹, GUO Fu-sheng², WANG Xiu-rong¹, DENG Guo-hua¹, SHI Jian-zhong¹, TIAN Guo-bin¹, ZENG Xian-ying¹

¹State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China
² China Animal Health and Epidemiology Center, Qingdao 266032, P.R.China

Received:2021-05-28 Accepted:2021-08-27 Online:2022-05-01 Published:2021-08-27
About author:Correspondence LIU Li-ling, Tel: +86-451-51051675, Fax: +86-451-51997166, E-mail: liuliling@caas.cn
Supported by:
The authors would like to thank DPRK Veterinary Department for the help of sample collection and transport. This work was supported by the China Agriculture Research System of MOF and MARA (CARS-41).

摘要/Abstract

摘要： 在过去的几十年，国内外研究人员对动物和人感染高致病性禽流感进行了全球范围的广泛监测，然而有关北朝鲜的禽流感流行病学研究数据却很少。在2013和2014年，在北朝鲜的家禽中多次暴发高致病性禽流感，我们分离到H5N1亚型高致病性禽流感病毒，进化分析显示分离到的2株病毒的HA基因高度同源，均属于2.3.2.1c分支，我们分析认为引起2014年鸡场禽流感暴发的病毒可能是由2013年Tudan鸭场病毒经迁徙野鸟引入。本实验的数据提供了禽流感病毒可以由野鸟-水禽-陆禽进行传播的直接证据。因此，我们必需加强水禽禽流感的监测和控制，这对预防和控制高致病性禽流感至关重要。

Abstract: In the past decade, there has been extensive global surveillance for highly pathogenic avian influenza (HPAI) infection in both animals and humans, however, few studies on epidemiology of avian influenza in Democratic People’s Republic of Korea (DPRK) were published. During the period 2013–2014, HPAI H5N1 viruses were detected with outbreaks in domestic poultry in DPRK. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to clade 2.3.2.1c with high homology. The HPAI H5N1 virus found in ducks at the Tudan Duck Farm in 2013 was might introduced by migratory birds and then led to the outbreaks on neighboring chicken farms in 2014. These data provide direct evidence for the transmission of avian influenza viruses from wild birds to waterfowl to terrestrial birds. Therefore, the monitoring and control of influenza virus in ducks must be given top priority, which are essential components to prevent and control HPAI.

Key words: avian influenza , H5N1 , Democratic People’s Republic of Korea , clade 2.3.2.1c

. [J]. Journal of Integrative Agriculture, 2022, 21(5): 1534-1538.

LIU Li-ling, YANG Huan-liang, GUO Fu-sheng, WANG Xiu-rong, DENG Guo-hua, SHI Jian-zhong, TIAN Guo-bin, ZENG Xian-ying. Emergence of H5N1 highly pathogenic avian influenza in Democratic People’s Republic of Korea[J]. Journal of Integrative Agriculture, 2022, 21(5): 1534-1538.

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Emergence of H5N1 highly pathogenic avian influenza in Democratic People’s Republic of Korea

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