Natural nematicidal active compounds: Recent research progress and outlook

doi:10.1016/S2095-3119(21)63617-1

摘要/Abstract

摘要：

植物寄生线虫是重要的致病性线虫，严重威胁着农业的可持续发展，每年给全球农业造成巨大的经济损失。防治植物寄生线虫的方法主要有培育抗病新品种、种植前土壤消毒、轮作、改变种植时间、休耕等。在诸多策略中，施用杀线虫剂是防治植物寄生线虫的有效方法之一。然而，杀线虫剂长期的重复使用增加了线虫产生抗药性的风险。随着人们环保意识的不断提高，高毒杀线虫剂已不符合现代农业的可持续发展。传统的杀线虫剂噻唑磷和阿维菌素因其对环境和人类健康的不利影响，在未来将会受到越来越多限制。当前，世界范围内植物线虫危害频发，导致杀线虫剂市场价值逐年增加，而杀线虫剂仍然面临着种类少和监管压力大的问题。因此，创制出高效、低风险的新型杀线虫剂是当前线虫综合防治所面临的巨大挑战。天然产物广泛存在于动物、植物和微生物中，它们具有广谱的生物活性，为人们提供多种多样的化学结构模型。许多农药或先导化合物都是天然产物，例如阿维菌素、鱼藤酮、乙蒜素、香兰素、肉桂酸和丁香酚等。由于一些天然产物具有独特的骨架结构、良好的药效基团和广谱的生物活性等诸多优势，近年来引起了药物开发者的广泛关注。研究人员在天然产物的分离和杀线虫线虫活性研究方面做了大量的工作。本工作综述了近10年来醇、酚、醛、酮、酸、酯、酰胺、生物碱、萜和多肽等天然杀线虫活性化合物的研究进展，从天然产物的来源、构效关系和作用机理等方面进行了分类讨论。然后，在天然产物开发和应用的基础上，展望了天然产物杀线虫剂的发展前景，旨在为新型杀线虫剂的发现提供新的思路和启发。

Abstract:

Plant-parasitic nematodes cause substantial economic losses to global agriculture yearly. The use of nematicides is an effective way of controlling plant-parasitic nematodes. However, the long-term use of traditional organophosphorus and carbamate chemical nematicides can lead to increased nematode resistance. With the increasing awareness of the necessity for the protection of the environment and human health, highly toxic nematicides no longer meet the developmental requirements of modern agriculture. Recently, many studies have been undertaken on the isolation and nematicidal activity of natural products against plant-parasitic nematodes and Caenorhabditis elegans. As an important model nematode, C. elegans plays a vital reference role in studying plant-parasitic nematodes regarding nematicidal activity, metabolic mechanism, and modes of action and target. We reviewed the latest research progress of natural nematicidal active compounds against plant-parasitic nematodes and C. elegans over the past ten years, discussed the structure-activity relationship and mechanism of action, and examined the development and application of natural nematicidal active compounds.

Key words: natural products , nematicides , research progress , plant-parasitic nematodes

. [J]. Journal of Integrative Agriculture, 2021, 20(8): 2015-2031.

CHEN Ji-xiang, SONG Bao-an. Natural nematicidal active compounds: Recent research progress and outlook[J]. Journal of Integrative Agriculture, 2021, 20(8): 2015-2031.

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