Geminiviruses and their application in biotechnology

doi:10.1016/S2095-3119(17)61702-7

摘要/Abstract

Abstract: Being a major class of single-stranded DNA viruses, geminiviruses are mostly studied due to their catastrophic infectious effect on crops. These DNA viruses are characteristic for their ability in quickly multiplying viral genetic materials without integrating into the genome of plants, which makes them ideal for developing viral vectors for plants bioengineering. Geminivirus-derived vectors can be classified into expression vectors and virus-induced gene silencing (VIGS) vectors. Details of the design, construction, application and improvements of these geminivirus vectors are summarized and discussed.

Key words: geminivirus , virus-based vectors , expression vectors , VIGS vectors , biotechnology

. [J]. Journal of Integrative Agriculture, 2017, 16(12): 2761-2771.

YANG Qiu-ying, DING Bo, ZHOU Xue-ping. Geminiviruses and their application in biotechnology[J]. Journal of Integrative Agriculture, 2017, 16(12): 2761-2771.

参考文献

Akbar Behjatnia S A, Dry I B, Ali Rezaian M. 1998. Identification of the replication-associated protein binding domain within the intergenic region of tomato leaf curl geminivirus. Nucleic Acids Research, 26, 925–931.

Ali S, Taylor W C. 2001. The 3’ non-coding region of a C4 photosynthesis gene increases transgene expression when combined with heterologous promoters. Plant Molecular Biology, 46, 325–333.

Baltes N J, Gil-Humanes J, Cermak T, Atkins P A, Voytas D F. 2014. DNA replicons for plant genome engineering. The Plant Cell, 26, 151–163.

Baulcombe D C. 1996. RNA as a target and an initiator of post-transcriptional gene silencing in transgenic plants. Plant Molecular Biology, 32, 79–88.

Buragohain A K, Sung Y K, Coffin R S, Coutts R H. 1994.The infectivity of dimeric potato yellow mosaic geminivirus clones in different hosts. The Journal of General Virology, 75, 2857–2861.

Carrillo-Tripp J, Shimada-Beltran H, Rivera-Bustamante R. 2006. Use of geminiviral vectors for functional genomics. Current Opinion in Plant Biology, 9, 209–215.

Castillo-Gonzalez C, Liu X, Huang C, Zhao C, Ma Z, Hu T, Sun F, Zhou Y, Zhou X, Wang X J, Zhang X. 2015.Geminivirus-encoded TrAP suppressor inhibits the histone methyltransferase SUVH4/KYP to counter host defense. eLife, 4, e06671.

Chen Q, He J, Phoolcharoen W, Mason H S. 2011. Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants. Human Vaccines, 7, 331–338.

Christensen N, Tilsner J, Bell K, Hammann P, Parton R, Lacomme C, Oparka K. 2009. The 5´ cap of tobacco mosaic virus (TMV) is required for virion attachment to the actin/endoplasmic reticulum network during early infection. Traffic, 10, 536–551.

Chung H Y, Lee H H, Kim K I, Chung H Y, Hwang-Bo J, Park J H, Sunter G, Kim J B, Shon D H, Kim W, Chung I S. 2011. Expression of a recombinant chimeric protein of hepatitis A virus VP1-Fc using a replicating vector based on Beet curly top virus in tobacco leaves and its immunogenicity in mice. Plant Cell Reports, 30, 1513–1521.

Dinesh-Kumar S P, Anandalakshmi R, Marathe R, Schiff M, Liu Y. 2003. Virus-induced gene silencing. Methods in Molecular Biology, 236, 287–294.

Eini O, Behjatnia S A. 2016. The minimal sequence essential for replication and movement of Cotton leaf curl Multan betasatellite DNA by a helper virus in plant cells. Virus Genes, 52, 679–687.

Esparza-Araiza M J, Banuelos-Hernandez B, Arguello-Astorga G R, Lara-Avila J P, Goodwin P H, Isordia-Jasso M I, Castillo-Collazo R, Rougon-Cardoso A, Alpuche-Solis A G. 2015. Evaluation of a SUMO E2 conjugating enzyme involved in resistance to Clavibacter michiganensis Subsp. michiganensis in Solanum peruvianum, through a Tomato Mottle Virus VIGS assay. Frontiers in Plant Science, 6, 1019.

Fire A, Xu S, Montgomery M K, Kostas S A, Driver S E, Mello C C. 1998, Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391, 806–811.

Fofana I B, Sangare A, Collier R, Taylor C, Fauquet C M. 2004, A geminivirus-induced gene silencing system for gene function validation in cassava. Plant Molecular Biology, 56, 613–624.

Frischmuth T, Stanley J. 1998. Recombination between viral DNA and the transgenic coat protein gene of African cassava mosaic geminivirus. The Journal of General Virology, 79, 1265–1271.

Fu D Q, Zhu B Z, Zhu H L, Zhang H X, Xie Y H, Jiang W B, Zhao X D, Luo K B. 2006, Enhancement of virus-induced gene silencing in tomato by low temperature and low humidity. Molecules and Cells, 21, 153–160.

Gao S J, Damaj M B, Park J W, Beyene G, Buenrostro-Nava M T, Molina J, Wang X, Ciomperlik J J, Manabayeva S A, Alvarado V Y, Rathore K S, Scholthof H B, Mirkov T E. 2013. Enhanced transgene expression in sugarcane by co-expression of virus-encoded RNA silencing suppressors. PLoS ONE, 8, e66046.

Gardiner W E, Sunter G, Brand L, Elmer J S, Rogers S G, Bisaro D M. 1988. Genetic analysis of tomato golden mosaic virus: the coat protein is not required for systemic spread or symptom development. The EMBO Journal, 7, 899–904.

Ghandi A, Adi M, Lilia F, Linoy A, Or R, Mikhail K, Mouhammad Z, Henryk C, Rena G. 2016. Tomato yellow leaf curl virus infection mitigates the heat stress response of plants grown at high temperatures. Scientific Reports, 6, 19715.

Golenberg E M, Sather D N, Hancock L C, Buckley K J, Villafranco N M, Bisaro D M. 2009. Development of a gene silencing DNA vector derived from a broad host range geminivirus. Plant Methods, 5, 9.

Gould R. 2016. Genetically Engineered Crops: Experiences and Prospects. The National Academies of Sciences, Engineering, and Medicine, Washington, D.C.

Gover O, Peretz Y, Mozes-Koch R, Maori E, Rabinowitch H D, Sela I. 2014. Only minimal regions of tomato yellow leaf curl virus (TYLCV) are required for replication, expression and movement. Archives of Virology, 159, 2263–2274.

Gu Z, Huang C, Li F, Zhou X. 2014. A versatile system for functional analysis of genes and microRNAs in cotton. Plant Biotechnology Journal, 12, 638–649.

Guan C, Zhou X. 2006. Phloem specific promoter from a satellite associated with a DNA virus. Virus research, 115, 150–157.

Hong S H, Kim K I, Chung H Y, Kim Y J, Sunter G, Bisaro D M, Chung I S. 2004. Expression of recombinant endostatin in Agrobacterium-inoculated leaf disks of Nicotiana tabacum var. Xanthi. Biotechnology Letters, 26, 1433–1439.

Howell S H, Walker L L, Dudley R K. 1980. Cloned Cauliflower Mosaic Virus DNA infects turnips (Brassica rapa). Science, 208, 1265–1267.

Huang C, Xie Y, Zhou X. 2009. Efficient virus-induced gene silencing in plants using a modified geminivirus DNA1 component. Plant Biotechnology Journal, 7, 254–265.

Huang C J, Zhang T, Li F F, Zhang X Y, Zhou X P. 2011. Development and application of an efficient virus-induced gene silencing system in Nicotiana tabacum using geminivirus alphasatellite. Journal of Zhejiang University (Science B, Biomedicine & Biotechnology), 12, 83–92.

Hull R. 1978. The possible use of plant viral DNAs in genetic manipulation in plants. Trends in Biochelnical Sciences, 3, 254–256.

Jackel J N, Buchmann R C, Singhal U, Bisaro D M. 2015, Analysis of geminivirus AL2 and L2 proteins reveals a novel AL2 silencing suppressor activity. Journal of Virology, 89, 3176–3187.

Jeyabharathy C, Shakila H, Usha R. 2015, Development of a VIGS vector based on the beta-satellite DNA associated with bhendi yellow vein mosaic virus. Virus Research, 195, 73–78.

Kennerdell J R, Carthew R W. 2000. Heritable gene silencing in Drosophila using double-stranded RNA. Nature Biotechnology, 18, 896–898.

Kharazmi S, Ataie Kachoie E, Behjatnia S A. 2016. Cotton leaf curl Multan betasatellite DNA as a tool to deliver and express the human B-cell lymphoma 2 (Bcl-2) gene in plants. Molecular Biotechnology, 58, 362–372.

Kim K I, Sunter G, Bisaro D M, Chung I S. 2007, Improved expression of recombinant GFP using a replicating vector based on Beet curly top virus in leaf-disks and infiltrated Nicotiana benthamiana leaves. Plant Molecular Biology, 64, 103–112.

Kjemtrup S, Sampson K S, Peele C G, Nguyen L V, Conkling M A, Thompson W F, Robertson D. 1998. Gene silencing from plant DNA carried by a Geminivirus. The Plant Journal, 14, 91–100.

Krenz B, Wege C, Jeske H. 2010. Cell-free construction of disarmed Abutilon mosaic virus-based gene silencing vectors. Journal of Virological Methods, 169, 129–137.

Kumar J, Gunapati S, Kumar J, Kumari A, Kumar A, Tuli R, Singh S P. 2014. Virus-induced gene silencing using a modified betasatellite: a potential candidate for functional genomics of crops. Archives of Virology, 159, 2109–2113.

Kushwaha N K, Chakraborty S. 2017. Chilli leaf curl virus-based vector for phloem-specific silencing of endogenous genes and overexpression of foreign genes. Applied Microbiology and Biotechnology, 101, 2121–2129.

Li C, He X, Luo X, Xu L, Liu L, Min L, Jin L, Zhu L, Zhang X. 2014.Cotton WRKY1 mediates the plant defense-to-development transition during infection of cotton by Verticillium dahliae by activating JASMONATE ZIM-DOMAIN1 expression. Plant Physiology, 166, 2179–2194.

Lu R, Martin-Hernandez A M, Peart J R, Malcuit I, Baulcombe D C. 2003. Virus-induced gene silencing in plants. Methods, 30, 296–303.

Lu Y, Zhu J K. 2017. Precise editing of a target base in the rice genome using a modified CRISPR/Cas9 system. Molecular Plant, 10, 523–525.

Nakade S, Yamamoto T, Sakuma T. 2017. Cas9, Cpf1 and C2c1/2/3 - What’s next? Bioengineered, 8, 265–273.

Napoli C, Lemieux C, Jorgensen R. 1990. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. The Plant Cell, 2, 279–289.

Pandey P, Choudhury N R, Mukherjee S K. 2009. A geminiviral amplicon (VA) derived from Tomato leaf curl virus (ToLCV) can replicate in a wide variety of plant species and also acts as a VIGS vector. Virology Journal, 6, 152.

Peele C, Jordan C V, Muangsan N, Turnage M, Egelkrout E, Eagle P, Hanley-Bowdoin L, Robertson D. 2001. Silencing of a meristematic gene using geminivirus-derived vectors. The Plant Journal: For Cell and Molecular Biology, 27, 357–366.

Peyret H, Lomonossoff G P. 2015, When plant virology met Agrobacterium: The rise of the deconstructed clones. Plant Biotechnology Journal, 13, 1121–1135.

Regnard G L, Halley-Stott R P, Tanzer F L, Hitzeroth, I I, Rybicki E P. 2010. High level protein expression in plants through the use of a novel autonomously replicating geminivirus shuttle vector. Plant Biotechnology Journal, 8, 38–46.

Reichel M, Li Y, Li J, Millar A A. 2015. Inhibiting plant microRNA activity: molecular SPONGEs, target MIMICs and STTMs all display variable efficacies against target microRNAs. Plant Biotechnology Journal, 13, 915–926.

Rodriguez-Negrete E, Lozano-Duran R, Piedra-Aguilera A, Cruzado L, Bejarano E R, Castillo A G. 2013. Geminivirus rep protein interferes with the plant DNA methylation machinery and suppresses transcriptional gene silencing. The New Phytologist, 199, 464–475.

Romano N, Macino G. 1992, Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences. Molecular Microbiology, 6, 3343–3353.

Sha A, Zhao J, Yin K, Tang Y, Wang Y, Wei X, Hong Y, Liu Y. 2014. Virus-based microRNA silencing in plants. Plant Physiology, 164, 36–47.

Shukla R, Dalal S, Malathi V G. 2013. Suppressors of RNA silencing encoded by tomato leaf curl betasatellites. Journal of Biosciences, 38, 45–51.

Soitamo A J, Jada B, Lehto K. 2012, Expression of geminiviral AC2 RNA silencing suppressor changes sugar and jasmonate responsive gene expression in transgenic tobacco plants. BMC Plant Biology, 12, 204.

Stanley J. 1995, Analysis of African cassava mosaic virus recombinants suggests strand nicking occurs within the conserved nonanucleotide motif during the initiation of rolling circle DNA replication. Virology, 206, 707–712.

Sunter G, Bisaro D M. 1997. Regulation of a geminivirus coat protein promoter by AL2 protein (TrAP): Evidence for activation and derepression mechanisms. Virology, 232, 269–280.

Tamilselvi D, Anand G, Swarup S. 2004. A geminivirus AYVV-derived shuttle vector for tobacco BY2 cells. Plant Cell Reports, 23, 81–90.

Tang Y, Lai Y, Liu Y. 2013, Virus-induced gene silencing using artificial miRNAs in Nicotiana benthamiana. Methods in Molecular Biology, 975, 99–107.

Townsend R, Watts J, Stanley J. 1986. Synthesis of viral DNA forms in Nicotiana plumbaginifolia protoplasts inoculated with cassava latent virus (CLV); evidence for the independent replication of one component of the CLV genome. Nucleic Acids Research, 14, 1253–1265.

Turnage M A, Muangsan N, Peele C G, Robertson D. 2002. Geminivirus-based vectors for gene silencing in Arabidopsis. The Plant Journal: For Cell and Molecular Biology, 30, 107–114.

Tuttle J R, Haigler C H, Robertson D. 2012. Method: Low-cost delivery of the cotton leaf crumple virus-induced gene silencing system. Plant Methods, 8, 27.

Tuttle J R, Haigler C H, Robertson D N. 2015. Virus-induced gene silencing of fiber-related genes in cotton. Methods in Molecular Biology, 1287, 219–234.

Unver T, Budak H. 2009, Virus-induced gene silencing, a post transcriptional gene silencing method. International Journal of Plant Genomics, 2009, 198680.

Varsani A, Roumagnac P, Fuchs M, Navas-Castillo J, Moriones E, Idris A, Briddon R W, Rivera-Bustamante R, Murilo Zerbini F, Martin D P. 2017. Capulavirus and Grablovirus: two new genera in the family Geminiviridae. Archives of Virology, 162,1819–1831.

Yan L, Wei S, Wu Y, Hu R, Li H, Yang W, Xie Q. 2015. High-efficiency genome editing in Arabidopsis using YAO promoter-driven CRISPR/Cas9 system. Molecular Plant, 8, 1820–1823.

Yang Q, Yang X, Ding B, Zhou X. 2016. The application of geminiviruses in biotechnology. Scientia Sinica Vitae, 46, 524–534. (in Chinese)

Yang Q, Ye Q A, Liu Y. 2015. Mechanism of siRNA production from repetitive DNA. Genes & Development, 29, 526–537.

Yin K, Han T, Liu G, Chen T, Wang Y, Yu A Y, Liu Y. 2015. A geminivirus-based guide RNA delivery system for CRISPR/Cas9 mediated plant genome editing. Scientific Reports, 5, 14926.

Zhang J, Dong J, Xu Y, Wu J. 2012a. V2 protein encoded by Tomato yellow leaf curl China virus is an RNA silencing suppressor. Virus Research, 163, 51–58.

Zhang J, Zhang X, Wang Y, Hou H, Qian Y. 2012b.Characterization of sequence elements from Malvastrum yellow vein betasatellite regulating promoter activity and DNA replication. Virology Journal, 9, 234.

Zhang T, Xu X, Huang C, Qian Y, Li Z, Zhou X. 2015. A novel DNA motif contributes to selective replication of a geminivirus-associated betasatellite by a helper virus-encoded replication-related protein. Journal of Virology, 90, 2077–2089.

Zhao J, Zhang X, Hong Y, Liu Y. 2016. Chloroplast in plant-virus interaction. Frontiers in Microbiology, 7, 1565.