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| Pyraclostrobin-loaded poly (lactic-co-glycolic acid) nanospheres: Preparation and characteristics |
| YIN Ming-ming, ZHENG Yu, CHEN Fu-liang |
| Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China |
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Abstract We used poly (lactic-co-glycolic acid) (PLGA) as a carrier polymer for pyraclostrobin-loaded nanospheres. Using the ultrasound emulsification-solvent evaporation method, the physicochemical characteristics and release properties of the pyraclostrobin-loaded nanospheres were studied by dialysis. The optimal nanospheres prepared had a diameter of 0.6 μm, an active ingredient loading of 17.2%, and a loading rate of 89.7%. Infrared spectroscopy data and differential scanning calorimetry revealed that pyraclostrobin was successfully embedded in the carrier PLGA, and photostability tests indicated enhanced ultraviolet resistance of pyraclostrobin-loaded PLGA nanospheres nanospheres. Release property testing indicated that smaller particles had a faster release rate. Nanospheres also had a faster release rate in slightly acidic and slightly basic environments than in a neutral condition. Agitated nanospheres had a faster release rate than immobile nanospheres. The cumulative release kinetics of pyraclostrobin-loaded nanospheres was consistent with the first order kinetic equation and the Weibull equation.
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Received: 24 May 2017
Accepted:
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| Fund: This study was supported by the National Key R&D Program of China (2017YFD0200301, 2016YFD0200500). |
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Corresponding Authors:
Correspondence CHEN Fu-liang, E-mail: flchen@ippcaas.cn
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| About author: YIN Ming-ming, E-mail: mmyin@ippcaas.cn; |
Cite this article:
YIN Ming-ming, ZHENG Yu, CHEN Fu-liang.
2018.
Pyraclostrobin-loaded poly (lactic-co-glycolic acid) nanospheres: Preparation and characteristics. Journal of Integrative Agriculture, 17(08): 1822-1832.
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